Description

17Beta-Estradiol-16,16,17-D3 is a high-purity, stable isotope-labeled analog of the primary female sex hormone, estradiol. This deuterated compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is a critical reagent for pharmaceutical R&D, clinical research, and bioanalytical laboratories focused on endocrinology, drug metabolism, and pharmacokinetic studies.

Application

• LC-MS/MS Internal Standard: Primary application as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for precise measurement of endogenous estradiol levels.
• Pharmaceutical Development: Used in the research, development, and quality control of hormone-based therapeutics and drug metabolism studies (DMPK).
• Clinical Diagnostics: Enables accurate and sensitive measurement of estradiol in patient serum, plasma, and urine samples for diagnostic testing.
• Endocrine Research: A vital tool for studying estrogen receptor binding, hormone signaling pathways, and endocrine-disrupting chemical effects.
• Forensic Toxicology: Applied in the confirmation and quantification of steroid hormones in anti-doping and forensic analyses.
• Biomarker Validation: Supports the validation of estradiol as a biomarker in various clinical and research settings.

Basic Information

Product Name	17Beta-Estradiol-16,16,17-D3
CAS No.	79037-37-9
Molecular Formula	C18H21D3O2
Molecular Weight	275.40 g/mol
Synonyms	Estradiol-d3; [16,16,17-D3]-17β-Estradiol; Deuterated Estradiol; 1,3,5(10)-Estratrien-3,17β-diol-16,16,17-d3; 17β-Estradiol-16,16,17-d3; E2-d3; NSC 113891-d3
EINECS	Contact for details

Quality Control

Every batch of 17Beta-Estradiol-16,16,17-D3 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments. Certificates of Analysis (COA) are supplied with each shipment, detailing purity (by HPLC), isotopic enrichment, and confirming identity and absence of significant impurities. Our quality commitment ensures consistency and reliability for your critical analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storing at -20°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in ethanol, DMSO; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.