Description

H-Thr-Nhme is a high-purity, protected amino acid derivative, specifically the methylamide of N-Boc-L-threonine. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering precise control over molecular structure and stereochemistry. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic agents, diagnostic tools, and advanced biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of threonine residues into peptide chains.
• Pharmaceutical Research: Used in the development of peptide-based drugs, hormones, and enzyme inhibitors.
• Bioconjugation: Serves as a linker or spacer molecule for attaching peptides to other biomolecules, polymers, or surfaces.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Industrial R&D: Fundamental reagent for studying protein structure-function relationships and metabolic pathways.

Basic Information

Product Name	H-Thr-Nhme
CAS No.	79009-37-3
Molecular Formula	C10H20N2O4
Molecular Weight	232.28 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-threonine methylamide; Boc-Thr-NHMe; (2S,3R)-2-[(tert-Butoxycarbonyl)amino]-3-hydroxy-N-methylbutanamide; H-L-Thr(Boc)-NHMe; Boc-L-Threonine Methylamide; tert-Butyloxycarbonyl-L-threonine methylamide; L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-, methylamide
EINECS	Contact for details

Quality Control

Our H-Thr-Nhme is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR/IR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.