Description

n-Benzoxycarbonyl-A-Hydroxyglycine is a protected amino acid derivative, specifically a Z-protected hydroxamate, serving as a crucial chiral building block in advanced organic synthesis. Its primary value lies in enabling the controlled construction of complex peptide and peptidomimetic structures, where it acts as a key intermediate for introducing specific functional groups. This high-purity compound is essential for research and development chemists in the pharmaceutical, biotechnology, and fine chemical industries, particularly for the synthesis of protease inhibitors and other bioactive molecules. The product is supplied under stringent quality control to ensure batch-to-batch consistency for sensitive applications.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially protease inhibitors and enzyme-targeted therapies.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate hydroxamate or hydroxyglycine motifs into peptide chains.
• Chemical Biology Research: Serves as a building block for creating chemical probes, activity-based protein profiling (ABPP) reagents, and metalloenzyme inhibitors.
• Fine Chemical Production: Intermediate in the multi-step synthesis of complex, high-value specialty chemicals and catalysts.
• Academic & Industrial R&D: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	n-Benzoxycarbonyl-A-Hydroxyglycine
CAS No.	79002-45-2
Molecular Formula	C10H11NO5
Molecular Weight	225.20 g/mol
Synonyms	Z-Hydroxyglycine-OH; N-Cbz-Hydroxyglycine; (Benzyloxycarbonyl)hydroxyglycine; N-(Benzyloxycarbonyl)hydroxyglycine; N-Carbobenzoxy-hydroxyglycine; Hydroxyglycine, N-benzyloxycarbonyl-; 2-[[(Benzyloxy)carbonyl]amino]-2-hydroxyacetic acid; 2-Hydroxy-2-[(phenylmethoxy)carbonylamino]acetic acid
EINECS	Contact for details

Quality Control

Our n-Benzoxycarbonyl-A-Hydroxyglycine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment. We support compliance with REACH and other relevant global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.