Description

1-Methoxy-4-Trifluoromethylsulfanyl-Benzene is a high-purity, specialized aromatic compound featuring a unique trifluoromethylthio (-SCF₃) functional group. This structural motif is highly valuable for its ability to modulate the lipophilicity, metabolic stability, and binding affinity of molecules in advanced chemical synthesis. It serves as a critical building block for researchers and process chemists in the pharmaceutical and agrochemical sectors. The compound is essential for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for introducing the -SCF₃ moiety into drug candidates, particularly in medicinal chemistry for CNS, oncology, and anti-infective research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the trifluoromethylthio group enhances biological activity and environmental stability.
• Material Science Precursor: Employed in the synthesis of advanced organic electronic materials, liquid crystals, and polymers with tailored electronic properties.
• Cross-Coupling Reactions: Serves as a versatile substrate in palladium-catalyzed Suzuki, Stille, and other cross-coupling reactions to create complex biaryl structures.
• Fluorine Chemistry Research: An important reagent for studying the effects of fluorine and sulfur incorporation on molecular properties in academic and industrial R&D.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of proprietary compounds and clinical trial materials.

Basic Information

Product Name	1-Methoxy-4-Trifluoromethylsulfanyl-Benzene
CAS No.	78914-94-0
Molecular Formula	C₈H₇F₃OS
Molecular Weight	208.20 g/mol
Synonyms	4-(Trifluoromethylthio)anisole; p-(Trifluoromethylthio)anisole; 1-Methoxy-4-(trifluoromethylthio)benzene; 4-Methoxyphenyl trifluoromethyl sulfide; Anisole, 4-(trifluoromethylthio)-; Benzene, 1-methoxy-4-[(trifluoromethyl)thio]-
EINECS	Contact for details

Quality Control

Our 1-Methoxy-4-Trifluoromethylsulfanyl-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP, ISO, and REACH standards for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.