Description

Angiotensin II, Sar(1)-Ala(7)- is a synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, specifically modified to act as a potent and selective antagonist at the AT1 receptor. This compound is a critical research tool for studying the renin-angiotensin system (RAS), which is central to cardiovascular physiology and pathology. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cardiovascular drug discovery, hypertension research, and metabolic studies.

Application

• Pharmacological Research: Used as a standard AT1 receptor antagonist to investigate the mechanisms of the renin-angiotensin system in vitro and in vivo.
• Cardiovascular Disease Models: Essential for creating and validating experimental models of hypertension, heart failure, and vascular remodeling.
• Drug Discovery & Screening: Serves as a reference compound in high-throughput screening assays to identify and characterize novel antihypertensive agents.
• Biochemical Studies: Employed in receptor binding assays and signal transduction studies to elucidate AT1 receptor function and downstream pathways.
• Academic & Educational Use: A key reagent in university laboratories for teaching advanced concepts in endocrinology and peptide pharmacology.

Basic Information

Product Name	Angiotensin II, Sar(1)-Ala(7)-
CAS No.	78809-85-5
Molecular Formula	C47H68N14O11
Molecular Weight	997.1 g/mol
Synonyms	Saralasin; [Sar1,Ala8]-Angiotensin II; 1-Sarcosine-8-alanine-angiotensin II; Sarcosyl1-Alanine8-Angiotensin II; Angiotensin II Antagonist; P-113; NSC-329853
EINECS	Contact for details

Quality Control

Our Angiotensin II, Sar(1)-Ala(7)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Custom synthesis to meet specific purity or packaging requirements is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.