Description

Acth (1-38), Phe(2)-Nle(4)- is a synthetic peptide fragment of adrenocorticotropic hormone (ACTH) with a specific amino acid substitution at position 4, where norleucine (Nle) replaces methionine. This modification enhances its stability and makes it a valuable research-grade biochemical tool for studying the structure-activity relationships of ACTH and related melanocortin receptors. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies engaged in endocrinology, neurobiology, and peptide drug discovery.

Application

• Biochemical Research: Used as a reference standard and active probe in studies of ACTH receptor binding, signal transduction, and melanocortin system function.
• Pharmaceutical Development: Serves as a key intermediate or lead compound in the discovery and optimization of novel peptide-based therapeutics targeting metabolic and inflammatory pathways.
• Endocrinology Studies: Employed in in vitro and in vivo models to investigate adrenal cortex stimulation, steroidogenesis, and the stress response axis.
• Neuroscience Research: Applied in research exploring the role of melanocortins in feeding behavior, energy homeostasis, and neuroprotective mechanisms.
• Quality Control: Acts as a high-purity analytical standard for the identification and quantification of ACTH-related peptides in other preparations.

Basic Information

Product Name	Acth (1-38), Phe(2)-Nle(4)-
CAS No.	78783-29-6
Molecular Formula	C198H295N55O58S
Molecular Weight	4498.9 g/mol
Synonyms	ACTH (1-38), human; Adrenocorticotropic Hormone (1-38), human; [Phe2, Nle4]-ACTH (1-38); [Nle4]-ACTH (1-38); Norleucine4-ACTH (1-38); Corticotropin (1-38) fragment; H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH (with Nle substitution); Synthetic ACTH fragment
EINECS	Contact for details

Quality Control

Our Acth (1-38), Phe(2)-Nle(4)- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing purity, peptide content, and impurity profiles are available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content (AAA)	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.