Description

Calcitriol-D6 is a deuterated analog of the active form of Vitamin D3, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is critical for ensuring accuracy and reliability in quantitative mass spectrometry analyses. It is primarily utilized by pharmaceutical research and development laboratories, clinical diagnostic facilities, and contract research organizations (CROs) engaged in metabolic and pharmacokinetic studies.

Application

• Quantitative Mass Spectrometry: Serves as an essential internal standard for the precise quantification of endogenous calcitriol levels in biological matrices (e.g., serum, plasma) using LC-MS/MS.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug metabolism and concentration-time profiles for Vitamin D analogs in preclinical and clinical research.
• Clinical Diagnostics: Used in the development and validation of high-sensitivity assays for measuring Vitamin D status, aiding in the diagnosis of bone and mineral disorders.
• Drug Metabolism Research: Facilitates studies on the metabolic pathways and bioavailability of Vitamin D and related therapeutic compounds.
• Quality Control in Pharmaceutical Manufacturing: Acts as a reference standard in the quality assurance of calcitriol-based pharmaceutical products.

Basic Information

Product Name	Calcitriol-D6
CAS No.	78782-99-7
Molecular Formula	C₂₇H₃₈D₆O₃
Molecular Weight	422.66 g/mol
Synonyms	1,25-Dihydroxycholecalciferol-D6; 1,25-Dihydroxyvitamin D3-D6; 1,25(OH)₂D₃-D6; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1α,3β,25-triol-D6; Rocaltrol-D6 (deuterated analog); Calcijex-D6 (deuterated analog); Internal Standard for Calcitriol
EINECS	Contact for details

Quality Control

Our Calcitriol-D6 is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic purity (by MS), and related substances. We support compliance with cGMP and ISO 9001 standards for research and diagnostic use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, keep desiccated to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D6)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.