Description

S-Methylcaptopril is a key pharmaceutical intermediate and a derivative of the well-known ACE inhibitor, captopril. This compound is of significant importance for research and development in cardiovascular drug discovery and synthesis. It is primarily utilized by pharmaceutical manufacturers and R&D laboratories for the production of novel active pharmaceutical ingredients (APIs) and for metabolic studies. The product, S-Methylcaptopril CAS NO 78636-29-0, is supplied to meet the stringent quality demands of the global life sciences sector.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of captopril analogs and other angiotensin-converting enzyme (ACE) inhibitors.
• Active Pharmaceutical Ingredient (API) Development: Used in research for developing new cardiovascular drugs with modified pharmacokinetic profiles.
• Biochemical Research: Serves as a reference standard and tool compound in enzymatic studies related to the renin-angiotensin system.
• Metabolite Studies: Employed in pharmacological research to investigate the metabolic pathways of captopril and related therapeutics.
• Process Chemistry: Used in scale-up and optimization of synthetic routes for complex sulfur-containing molecules.

Basic Information

Product Name	S-Methylcaptopril
CAS No.	78636-29-0
Molecular Formula	C10H17NO3S
Molecular Weight	231.31 g/mol
Synonyms	(2S)-1-[(2S)-2-Methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid; S-Methylcaptopril; L-Captopril methyl derivative; (S)-1-[(S)-3-Mercapto-2-methylpropionyl]pyrrolidine-2-carboxylic acid; SQ 14,534 methyl derivative; ACE inhibitor intermediate
EINECS	Contact for details

Quality Control

Our S-Methylcaptopril is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S,S-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.