Description

Ethyl 2-(3-Fluoro-4-Nitrophenyl)Propionate is a high-purity fluorinated aromatic ester building block, essential for advanced organic synthesis. Its molecular structure, featuring both a fluorine substituent and a nitro group, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and anti-inflammatory agents.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or intermediate for synthesizing specialty polymers and liquid crystals with specific optical or electronic properties.
• Chemical Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) and nucleophilic aromatic substitution reactions due to its reactive nitro and fluorine groups.
• Dye and Pigment Intermediate: Acts as a precursor in the synthesis of complex fluorinated dyes and organic pigments.

Basic Information

Product Name	Ethyl 2-(3-Fluoro-4-Nitrophenyl)Propionate
CAS No.	78543-07-4
Molecular Formula	C11H12FNO4
Molecular Weight	241.22 g/mol
Synonyms	2-(3-Fluoro-4-nitrophenyl)propionic acid ethyl ester; Ethyl 2-(3-fluoro-4-nitrophenyl)propanoate; Ethyl α-methyl-3-fluoro-4-nitrobenzenepropanoate; 3-Fluoro-4-nitrophenylpropionic acid ethyl ester; 78543-07-4; Propanoic acid, 2-(3-fluoro-4-nitrophenyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-(3-Fluoro-4-Nitrophenyl)Propionate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or compatible light-blocking materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.