Description

3-Hydroxy Guanfacine o-β-D-Glucuronide is a key glucuronidated metabolite of the pharmaceutical agent guanfacine. This compound is of significant importance for pharmaceutical research and development, particularly in the areas of drug metabolism and pharmacokinetic (DMPK) studies. It serves as a critical reference standard for analytical method development and validation in bioanalytical laboratories. Researchers and quality control specialists in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors require this high-purity metabolite to ensure accurate quantification and understanding of the parent drug's metabolic profile.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantification of 3-Hydroxy Guanfacine and its glucuronide conjugate in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for in vitro and in vivo studies to elucidate the metabolic pathways, clearance mechanisms, and bioavailability of Guanfacine.
• Bioanalytical Method Development: Used to develop and validate sensitive LC-MS/MS, HPLC, or UPLC methods for pharmacokinetic and toxicokinetic assays.
• Clinical Research: Supports clinical trial studies by enabling accurate monitoring of metabolite levels in patient plasma, serum, or urine samples.
• Impurity Profiling: Acts as a known impurity or degradation product standard for the quality control of Guanfacine active pharmaceutical ingredient (API) and finished dosage forms.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., FDA, EMA) to demonstrate comprehensive understanding of a drug's metabolic fate.

Basic Information

Product Name	3-Hydroxy Guanfacine o-β-D-Glucuronide
CAS No.	78433-83-7
Molecular Formula	C18H27N3O9
Molecular Weight	429.42 g/mol
Synonyms	Guanfacine 3-O-Glucuronide; 3-Hydroxyguanfacine Glucuronide; 1-(2,6-Dichlorophenyl)acetyl-3-(β-D-glucopyranuronosyloxy)guanidine; Guanfacine Metabolite M2; Guanfacine Glucuronide Metabolite; N-(Aminoiminomethyl)-2,6-dichloro-3-(β-D-glucopyranuronosyloxy)benzeneacetamide
EINECS	Contact for details

Quality Control

Our 3-Hydroxy Guanfacine o-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide comprehensive Certificates of Analysis (COA) with batch-specific data, ensuring traceability and compliance with research-grade standards. Specifications are designed to meet the exacting requirements of analytical and pharmaceutical development laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For extended storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.