Description

Cyclobutanecarbonitrile, 3-(1-Pyrrolidinyl)-, trans- (9Ci) is a specialized organic nitrile building block featuring a trans-configured cyclobutane ring substituted with a pyrrolidine moiety. This compound is valued for its rigid, three-dimensional structure, making it a key intermediate in advanced pharmaceutical research and fine chemical synthesis. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral targets.
• Agrochemical Synthesis: Used in the design and synthesis of advanced crop protection agents and herbicides, leveraging its unique steric profile.
• Ligand and Catalyst Development: Acts as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or additive for producing polymers with specific thermal or mechanical properties.
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	Cyclobutanecarbonitrile, 3-(1-Pyrrolidinyl)-, trans- (9Ci)
CAS No.	78403-00-6
Molecular Formula	C9H14N2
Molecular Weight	150.22 g/mol
Synonyms	trans-3-(Pyrrolidin-1-yl)cyclobutanecarbonitrile; 3-(1-Pyrrolidinyl)cyclobutanecarbonitrile, trans-; trans-3-Pyrrolidin-1-ylcyclobutanecarbonitrile; (1r,3r)-3-(Pyrrolidin-1-yl)cyclobutanecarbonitrile; (trans)-3-(1-Pyrrolidinyl)cyclobutanecarbonitrile; 78403-00-6; Cyclobutanecarbonitrile, 3-(1-pyrrolidinyl)-, trans-
EINECS	Contact for details

Quality Control

Our Cyclobutanecarbonitrile, 3-(1-Pyrrolidinyl)-, trans- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and strong acids. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (trans-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.