Description

Tendamistat CAS NO 78362-18-2 is a potent and specific α-amylase inhibitor, a low molecular weight protein derived from *Streptomyces tendae*. This compound is of significant interest for its ability to precisely modulate starch digestion and carbohydrate metabolism. It serves as a critical research tool and a potential active ingredient for the pharmaceutical, nutraceutical, and biotechnology industries, particularly in the development of treatments for diabetes and obesity.

Application

• Biochemical Research: Used as a specific inhibitor in enzymatic studies to investigate α-amylase kinetics, structure, and function.
• Pharmaceutical Development: Serves as a lead compound or active pharmaceutical ingredient (API) in R&D for anti-diabetic and weight management drugs.
• Nutraceutical Formulations: Potential inclusion in dietary supplements aimed at moderating postprandial blood glucose levels by inhibiting dietary starch breakdown.
• Diagnostic Reagents: Employed in the development of in-vitro diagnostic kits and assays for measuring α-amylase activity in clinical samples.
• Enzyme Inhibition Studies: A standard tool for studying carbohydrate-active enzymes and for screening novel amylase inhibitors.
• Academic & Industrial R&D: Essential for universities and biotech companies conducting metabolic disorder research.

Basic Information

Product Name	Tendamistat
CAS No.	78362-18-2
Molecular Formula	C~74~H~113~N~21~O~28~S~2~
Molecular Weight	~1820 g/mol
Synonyms	Tendamistat; α-amylase inhibitor (Streptomyces tendae); HOE 467; Tendamistat (HOE 467); Amylase inhibitor from *S. tendae*; TENDAMISTAT, STREPTOMYCES TENDAE; Microbial α-amylase inhibitor; 2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S,41S,44S,47S,50S)-50-Amino-47-[(1S)-1-carboxyethyl]-44-[(1R)-1-carboxyethyl]-8-[(1S)-1-carboxyethyl]-5-[(1R)-1-carboxyethyl]-29-[(1R)-1-carboxyethyl]-38-[(1R)-1-carboxyethyl]-17-[(1R)-1-carboxyethyl]-20-[(1R)-1-carboxyethyl]-23-[(1R)-1-carboxyethyl]-26-[(1R)-1-carboxyethyl]-32-[(1R)-1-carboxyethyl]-35-[(1R)-1-carboxyethyl]-2-[(1R)-1-carboxyethyl]-11-[(1R)-1-carboxyethyl]-14-[(1R)-1-carboxyethyl]-41-[(1R)-1-carboxyethyl]-N~2~,N~5~,N~8~,N~11~,N~14~,N~17~,N~20~,N~23~,N~26~,N~29~,N~32~,N~35~,N~38~,N~41~,N~44~,N~47~-hexadecaacyl-1,4,7,10,13,16,19,22,25,28,31,34,37,40,43,46-hexadecaazacyclopentapentacontane-1,4,7,10,13,16,19,22,25,28,31,34,37,40,43,46-hexadecacarboxylic acid
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Quality Control

Our Tendamistat is produced and controlled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as purity, biological activity (amylase inhibition), and endotoxin levels where applicable.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Biological Activity (Amylase Inhibition)	≥ 90% of reference activity
Water Content (KF)	≤ 5.0%
Endotoxin (LAL)	< 10 EU/mg (for applicable grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.