Description

Nic-Osu CAS NO 78348-28-4 is a specialized chemical reagent widely recognized as an activated ester derivative of nicotinic acid. This compound is a critical building block in organic synthesis, particularly valued for its high reactivity in amide bond formation. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel compounds, including active pharmaceutical ingredients (APIs) and biochemical probes.

Application

• Peptide Synthesis: As a coupling reagent for the efficient formation of amide bonds in solid-phase and solution-phase peptide synthesis.
• Bioconjugation: For labeling proteins, antibodies, and other biomolecules with fluorescent dyes, drugs, or other functional groups.
• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, including nicotinic acid derivatives and receptor-targeting agents.
• Material Science: Used in the surface functionalization of polymers and nanoparticles to introduce specific chemical properties.
• Chemical Biology Research: Employed in the development of activity-based probes and other tools for studying enzyme function and protein interactions.
• Agrochemical Synthesis: An intermediate in the production of certain advanced crop protection agents.

Basic Information

Product Name	Nic-Osu
CAS No.	78348-28-4
Molecular Formula	C11H8N2O5
Molecular Weight	248.19 g/mol
Synonyms	Nicotinic Acid N-Hydroxysuccinimide Ester; Nicotinic Acid NHS Ester; 3-Pyridinecarboxylic Acid, 2,5-Dioxo-1-pyrrolidinyl Ester; 1-[(3-Carboxypyridin-1-ium-1-yl)oxy]-2,5-pyrrolidinedione; Nicotinic Acid Active Ester; Nic-NHS; Nicotinic Acid Succinimidyl Ester; Nicotinoyloxy Succinimide
EINECS	Contact for details

Quality Control

Our Nic-Osu is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and NMR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing specific results for purity, identity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under desiccant when not in use to prevent hydrolysis and maintain reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.