Description

3,4,5-Trifluorobenzamide is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. Its unique trifluoromethyl-substituted benzamide structure makes it a critical intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine motifs to enhance molecular properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the fluorine atoms improve bioavailability and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic display technologies.
• Polymer Modification: Acts as a monomer or additive to introduce fluorine into polymers, enhancing chemical resistance and thermal stability.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, amide bond formations, and other transformations to construct complex fluorinated molecules.
• Research & Development: Used in academic and industrial labs for method development and exploring new chemical entities.

Basic Information

Product Name	3,4,5-Trifluorobenzamide
CAS No.	78324-75-1
Molecular Formula	C7H4F3NO
Molecular Weight	175.11 g/mol
Synonyms	3,4,5-Trifluorobenzoic acid amide; Benzamide, 3,4,5-trifluoro-; 3,4,5-Trifluorobenzene-1-carboxamide; 3,4,5-Trifluorobenzoamide; 1-Carbamoyl-3,4,5-trifluorobenzene
EINECS	Contact for details

Quality Control

Our 3,4,5-Trifluorobenzamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical and agrochemical applications. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.