Description

5-[[2-(Acetyloxy)Acetyl]Amino]-2,4,6-Triiodo-1,3-Benzenedicarbonyl Dichloride is a high-purity, iodinated aromatic compound primarily used as a critical intermediate in advanced pharmaceutical synthesis. This compound matters because it provides the essential triiodobenzene core required for manufacturing modern, high-contrast X-ray and CT imaging agents. Pharmaceutical R&D and manufacturing facilities specializing in diagnostic contrast media are the primary industrial users of this precise chemical building block.

Application

• Key Intermediate for X-ray Contrast Media: Serves as a fundamental precursor in the synthesis of non-ionic, low-osmolar contrast agents like iopamidol, iohexol, and ioversol.
• Pharmaceutical Research & Development: Used in the discovery and process development of new iodinated diagnostic compounds for enhanced imaging safety and efficacy.
• Active Pharmaceutical Ingredient (API) Synthesis: Employed in multi-step synthetic routes to construct the complex molecular architecture of final contrast agent APIs.
• Chemical Derivatization Studies: Utilized in academic and industrial labs to create novel derivatives for evaluating structure-activity relationships in diagnostic applications.

Basic Information

Product Name	5-[[2-(Acetyloxy)Acetyl]Amino]-2,4,6-Triiodo-1,3-Benzenedicarbonyl Dichloride
CAS No.	78314-12-2
Molecular Formula	C13H7Cl2I3NO5
Molecular Weight	729.82 g/mol
Synonyms	5-Acetamido-2,4,6-triiodoisophthaloyl Dichloride; 5-[(2-Acetoxyacetyl)amino]-2,4,6-triiodoisophthaloyl Dichloride; 2,4,6-Triiodo-5-[(2-acetoxyacetylamino)]isophthaloyl Dichloride; Iopamidol Intermediate; Iohexol Intermediate; 5-[(Acetyloxy)acetyl]amino]-2,4,6-triiodobenzene-1,3-dicarbonyl Dichloride; 78314-12-2; Triiodoisophthaloyl Dichloride Derivative
EINECS	Contact for details

Quality Control

Our 5-[[2-(Acetyloxy)Acetyl]Amino]-2,4,6-Triiodo-1,3-Benzenedicarbonyl Dichloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical synthesis. Quality is verified through comprehensive analytical testing including HPLC, NMR, and IR spectroscopy. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with each shipment to support your regulatory and process requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.