Description

2,4-Imidazolidinedione-2-13C-1,3-15N2, 5,5-Diphenyl- (9Ci) is a stable isotope-labeled analog of the pharmaceutical compound 5,5-diphenylhydantoin, a key structural motif. This compound is specifically designed for use as an internal standard in quantitative mass spectrometry, providing unmatched accuracy and reliability in analytical workflows. It is essential for researchers and quality control laboratories in the pharmaceutical, forensic, and clinical diagnostics sectors who require precise measurement of metabolites or related compounds.

Application

• Quantitative Mass Spectrometry (MS): Serves as a critical internal standard for LC-MS/MS and GC-MS methods, enabling accurate quantification of 5,5-diphenylhydantoin and its derivatives by compensating for instrument variability and matrix effects.
• Pharmaceutical Metabolism Studies: Used in pharmacokinetic (PK) and pharmacodynamic (PD) research to track and quantify drug metabolites in biological matrices like plasma, urine, and tissue homogenates.
• Clinical Research & Diagnostics: Facilitates the development and validation of high-precision diagnostic assays for therapeutic drug monitoring (TDM) of anticonvulsant therapies.
• Forensic Toxicology: Employed in confirmatory testing and method development for the precise identification and quantification of specific pharmaceuticals in forensic samples.
• Stable Isotope Labeling Research: Acts as a valuable chemical tool in studies investigating metabolic pathways, degradation mechanisms, and environmental fate using isotope tracing techniques.
• Reference Standard Manufacturing: Used by certified reference material (CRM) producers to create calibrated standards for ensuring global analytical consistency and compliance.

Basic Information

Product Name	2,4-Imidazolidinedione-2-13C-1,3-15N2, 5,5-Diphenyl- (9Ci)
CAS No.	78213-26-0
Molecular Formula	C14H12N2O2 (with 13C at position 2 and 15N2 at positions 1 & 3)
Molecular Weight	~242.26 g/mol (exact mass varies with isotopic enrichment)
Synonyms	5,5-Diphenylhydantoin-2-13C-1,3-15N2; Phenytoin-2-13C-1,3-15N2; 5,5-Diphenyl-2,4-imidazolidinedione-2-13C-1,3-15N2; Diphenylhydantoin-13C,15N2; Isotopically Labeled Phenytoin; [13C,15N2]-5,5-Diphenylhydantoin; [13C,15N2]-Phenytoin; Aleviatin-13C,15N2 (labeled)
EINECS	Contact for details

Quality Control

Every batch of our isotope-labeled materials is produced and analyzed under strict quality control protocols to ensure isotopic and chemical purity. We provide comprehensive Certificates of Analysis (COA) detailing isotopic enrichment (Atom % 13C and 15N), chemical purity by HPLC, and confirmatory data from NMR and mass spectrometry. Our production adheres to cGMP principles where applicable, supporting regulatory filings and research reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to labeled structure
Isotopic Enrichment (Atom % 13C)	≥ 99%
Isotopic Enrichment (Atom % 15N)	≥ 98%
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.