Description

[6R-[6Alpha,7Beta(R*)]]-7-[Amino(4-Hydroxyphenyl)Acetamido]-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid Monohydrochloride is a high-purity pharmaceutical intermediate, specifically the monohydrochloride salt of a cephalosporin nucleus derivative. This compound is of critical importance for the synthesis of advanced β-lactam antibiotics, offering a key chiral building block for pharmaceutical manufacturing. It is primarily required by pharmaceutical R&D laboratories, API (Active Pharmaceutical Ingredient) manufacturers, and fine chemical synthesis facilities engaged in developing next-generation antibacterial agents.

Application

• Key Intermediate in Cephalosporin Antibiotic Synthesis: Serves as a crucial precursor in the multi-step synthesis of advanced-generation cephalosporin antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the discovery and structural modification of new β-lactam compounds with improved efficacy and spectrum of activity.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the controlled production processes of final antibiotic drug substances under GMP (Good Manufacturing Practice) conditions.
• Process Chemistry & Scale-Up Studies: Utilized for optimizing synthetic routes, yield improvement, and process validation for commercial-scale production.
• Reference Standard: Can be used as a high-purity analytical standard for quality control and regulatory submission purposes.

Basic Information

Item	Details
Product Name	[6R-[6Alpha,7Beta(R*)]]-7-[Amino(4-Hydroxyphenyl)Acetamido]-3-Methyl-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid Monohydrochloride
CAS No.	78144-01-1
Molecular Formula	C17H19N3O5S • HCl
Molecular Weight	413.87 g/mol (Free base: 377.41 g/mol)
Synonyms	7-ADCA 4-Hydroxy Derivative HCl; 7-[(Amino(4-hydroxyphenyl)acetyl)amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride; 7-ACA 4-Hydroxy Phenoxy Acetamido Derivative HCl Salt; (6R,7R)-7-[(R)-2-Amino-2-(4-hydroxyphenyl)acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrochloride; Cephalosporin C Nucleus Derivative HCl; 4-Hydroxy-7-ADCA Hydrochloride; 7-ADCA, 7-substituted with 4-hydroxyphenylglycine, monohydrochloride
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and purity suitable for pharmaceutical applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support development and commercial projects requiring compliance with ICH guidelines and can tailor specifications to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%
Optical Rotation	Specific range provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.