Description

ω-(3-Diazirinophenoxy)Hexadecanoic Acid is a specialized, bifunctional chemical probe designed for advanced photoaffinity labeling and crosslinking studies. This compound integrates a long-chain fatty acid moiety with a photoreactive diazirine group, enabling covalent capture of transient biomolecular interactions upon UV light activation. It is an essential tool for researchers in pharmaceutical discovery and chemical biology who require precise mapping of protein-lipid interactions, membrane protein targets, and drug binding sites.

Application

• Photoaffinity Labeling (PAL): Covalent tagging of biological targets, such as enzymes, receptors, and transporters, for identification and isolation.
• Chemical Proteomics: Profiling of protein targets and off-targets for drug candidates and bioactive small molecules.
• Membrane Protein Studies: Investigation of lipid-protein interactions and the structural environment of integral membrane proteins.
• Activity-Based Protein Profiling (ABPP): Functional characterization of enzymes within complex proteomes using activity-directed probes.
• Drug Discovery: Elucidation of binding sites and mechanisms of action for novel therapeutic agents.
• Bioconjugation & Probe Development: Serving as a key synthetic intermediate for creating more complex diagnostic or therapeutic conjugates.

Basic Information

Product Name	ω-(3-Diazirinophenoxy)Hexadecanoic Acid
CAS No.	78112-02-4
Molecular Formula	C24H36N2O3
Molecular Weight	400.56 g/mol
Synonyms	16-(3-(3-(Trifluoromethyl)-3H-diazirin-3-yl)phenoxy)hexadecanoic acid; 3-(3-(Trifluoromethyl)diazirin-3-yl)phenoxy Palmitic Acid; Photoaffinity Labeling Probe; PAL Probe; Diazirine-Fatty Acid Conjugate; ω-(3-(3-(Trifluoromethyl)-3H-diazirin-3-yl)phenoxy)hexadecanoic acid; 16-[3-[3-(Trifluoromethyl)-3H-diazirin-3-yl]phenoxy]hexadecanoic acid
EINECS	Contact for details

Quality Control

Our ω-(3-Diazirinophenoxy)Hexadecanoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, critical for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF, chloroform

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.