Description

n-Fluoroacetylmannosamine is a chemically modified mannosamine derivative, serving as a critical precursor in metabolic glycoengineering and bioorthogonal chemistry. Its core value lies in enabling the site-specific introduction of fluorine atoms into cell surface glycans, facilitating advanced research and development in targeted therapeutics and diagnostics. This high-purity biochemical is essential for pharmaceutical researchers, biochemists, and diagnostic developers working on novel cancer therapies, live-cell imaging, and vaccine platform technologies.

Application

• Metabolic Glycoengineering (MGE): Precursor for the metabolic labeling of cell surface sialic acids with fluorine tags for subsequent bioorthogonal click chemistry reactions.
• Cancer Research & Therapy: Used in the development of targeted drug delivery systems and immunotherapies by modifying tumor-associated carbohydrate antigens.
• Live-Cell Imaging & Diagnostics: Enables non-invasive tracking and visualization of glycoconjugate dynamics in living systems for diagnostic assay development.
• Glycoprotein & Glycolipid Engineering: Tool for creating structurally defined, fluorinated glycoproteins and glycolipids to study structure-function relationships.
• Vaccine Development: Investigated as a component in the synthesis of neoglycoconjugate vaccines to elicit specific immune responses.
• Chemical Biology Probes: Serves as a building block for synthesizing activity-based probes to study glycosidase and glycosyltransferase enzymes.

Basic Information

Product Name	n-Fluoroacetylmannosamine
CAS No.	78103-27-2
Molecular Formula	C8H14FNO6
Molecular Weight	239.20 g/mol
Synonyms	ManNFAc; 2-Acetamido-2-deoxy-1-fluoro-D-mannose; N-Fluoroacetyl-D-mannosamine; 5-Acetamido-5-deoxy-2-fluoro-D-mannofuranose; 1-Fluoro-2-acetamido-2-deoxy-D-mannose; Ac4ManNFAc (peracetylated precursor); N-Fluoroacetylmannosamine; Fluorinated Mannosamine Derivative
EINECS	Contact for details

Quality Control

Every batch of n-Fluoroacetylmannosamine is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR (¹H & ¹⁹F), and Mass Spectrometry analyses. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (¹H & ¹⁹F NMR)
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.