Description

Gadolinium 1,4,7-Triazacyclononane-N,N',N''-Triacetic Acid is a highly stable macrocyclic chelate complex of the rare earth metal gadolinium. This compound is critical for its paramagnetic properties, which are essential for enhancing contrast in magnetic resonance imaging (MRI). It is primarily utilized by manufacturers of diagnostic imaging agents in the pharmaceutical and biotechnology sectors, as well as by research institutions developing next-generation contrast media.

Application

• MRI Contrast Agent Precursor: Serves as a key intermediate in the synthesis of advanced gadolinium-based contrast agents (GBCAs) for diagnostic imaging.
• Pharmaceutical Research & Development: Used in the development and testing of new macrocyclic contrast media known for their high kinetic stability and safety profiles.
• Bioconjugation Studies: Acts as a starting material for creating targeted contrast agents by conjugating with antibodies, peptides, or other biomolecules.
• Material Science: Employed in research involving lanthanide-doped materials for optical imaging, sensing, and catalysis.
• Quality Control & Reference Standard: Functions as a high-purity analytical reference standard for quality assurance in GBCA manufacturing.

Basic Information

Product Name	Gadolinium 1,4,7-Triazacyclononane-N,N',N''-Triacetic Acid
CAS No.	78085-51-5
Molecular Formula	C12H18GdN3O6
Molecular Weight	446.55 g/mol
Synonyms	Gadolinium NOTA; Gd(NOTA); Gadolinium-1,4,7-triazacyclononane-1,4,7-triacetate; Gadolinium(III) 1,4,7-triazacyclononane-N,N',N''-triacetate; NOTA-Gd; NOTA-Gd(III) complex; 1,4,7-Triazacyclononane-N,N',N''-triacetic acid gadolinium complex; Gd-DO3A (common misnomer, structurally related)
EINECS	Contact for details

Quality Control

Our Gadolinium NOTA is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, elemental analysis for Gd content, and specific tests for free gadolinium and related substances. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Gadolinium (Gd) Content	34.0 - 36.0 %
Free Gadolinium	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.