Description

3-(Trifluoroacetylamino)-1-Propanol is a versatile fluorinated organic building block characterized by its reactive amino alcohol functionality. This compound is valued for its role in introducing the trifluoroacetyl group and a short-chain alcohol spacer into more complex molecular architectures. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical and agrochemical sectors. Its unique structure makes it a key intermediate for synthesizing active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of novel drug candidates, particularly in medicinal chemistry programs targeting protease inhibitors and other bioactive molecules.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Peptide Mimetics & Linker Chemistry: Serves as a versatile spacer or linker in the synthesis of peptide analogs and bioconjugates, leveraging both the amino and hydroxyl groups.
• Material Science Research: Employed in the synthesis of fluorinated polymers, coatings, and specialty surfactants that require unique surface properties and chemical resistance.
• Chemical Biology Probes: Useful for creating fluorescent tags, affinity labels, and other molecular probes for biochemical and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the fine chemical and life science industries.

Basic Information

Product Name	3-(Trifluoroacetylamino)-1-Propanol
CAS No.	78008-15-8
Molecular Formula	C5H8F3NO2
Molecular Weight	171.12 g/mol
Synonyms	3-[(Trifluoroacetyl)amino]-1-propanol; 1-Propanol, 3-[(trifluoroacetyl)amino]-; N-(3-Hydroxypropyl)trifluoroacetamide; 3-(Trifluoroacetamido)propan-1-ol; Trifluoroacetamide, N-(3-hydroxypropyl)-; 3-Aminopropanol trifluoroacetamide; 3-(Trifluoroacetylamino)propanol; TFA-Propanolamine
EINECS	Contact for details

Quality Control

Our 3-(Trifluoroacetylamino)-1-Propanol is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.