Description

(4-(Azetidine-1-Carbonyl)Phenyl)Boronic Acid is a high-purity boronic acid derivative featuring an azetidine carbonyl moiety, making it a valuable building block in modern synthetic chemistry. Its core value lies in its dual functionality, serving as both a protected amine precursor and a key reactant in Suzuki-Miyaura cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for constructing complex molecular architectures in drug discovery and advanced material synthesis.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs), especially in kinase inhibitor and other small molecule drug candidates.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid partner for palladium-catalyzed carbon-carbon bond formation, enabling the construction of biaryl and heterobiaryl structures.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the synthesis of linker molecules and warhead components for targeted protein degradation therapeutics.
• Agrochemical Synthesis: Employed in the research and production of novel herbicides and fungicides with complex aromatic backbones.
• Material Science & OLED Development: Acts as a precursor for creating organic electronic materials, including charge-transport layers and emissive materials in OLED displays.
• Chemical Biology & Bioconjugation: Utilized as a handle for site-specific labeling and modification of biomolecules due to its selective reactivity.

Basic Information

Item	Details
Product Name	(4-(Azetidine-1-Carbonyl)Phenyl)Boronic Acid
CAS No.	77956-92-4
Molecular Formula	C10H12BNO3
Molecular Weight	205.02 g/mol
Synonyms	4-(Azetidine-1-carbonyl)benzeneboronic acid; [4-(Azetidine-1-carbonyl)phenyl]boronic acid; 1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl]azetidine (Pinacol ester precursor); B-[4-(Azetidine-1-carbonyl)phenyl]boronic acid; 4-(Azetidine-1-carbonyl)phenylboronic acid; 4-(N-Azetidinylcarbonyl)phenylboronic acid
EINECS	Contact for details

Quality Control

Our (4-(Azetidine-1-Carbonyl)Phenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with stringent industry standards for advanced intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.