Description

Thymidine 3'-Acetate=5'-[Bis(2,2-Dimethyl-1-Aziridinyl)Phosphinic Acid] is a specialized nucleotide analog derivative, identified by CAS No. 77887-07-1, designed for advanced biochemical and pharmaceutical research. This compound is a critical building block and intermediate in the synthesis of modified oligonucleotides and prodrugs, offering unique reactivity for targeted molecular modifications. It is primarily utilized by researchers and manufacturers in the fields of nucleic acid chemistry, antiviral drug development, and molecular biology, where precise chemical tools are essential for innovation.

Application

• Intermediate for Antiviral Prodrug Synthesis: A key precursor in the development of nucleotide-based antiviral agents, particularly for hepatitis and HIV research.
• Oligonucleotide Modification: Used to introduce specific functional groups or labels into DNA/RNA strands for diagnostic and therapeutic applications.
• Biochemical Research Reagent: Serves as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and DNA repair pathways.
• Pharmaceutical Intermediate: Employed in the multi-step synthesis of novel nucleoside analogs with potential therapeutic activity.
• Probe Development: Facilitates the creation of labeled nucleotides for use in imaging, sequencing, and hybridization assays.
• Cross-linking Studies: The aziridinyl phosphinic acid moiety can be utilized for studying DNA-protein interactions or creating covalent conjugates.

Basic Information

Product Name	Thymidine 3'-Acetate=5'-[Bis(2,2-Dimethyl-1-Aziridinyl)Phosphinic Acid]
CAS No.	77887-07-1
Molecular Formula	C19H31N4O8P
Molecular Weight	474.45 g/mol
Synonyms	5'-[Bis(2,2-dimethylaziridin-1-yl)phosphinyl]thymidine 3'-acetate; Thymidine, 3'-acetate 5'-[bis(2,2-dimethyl-1-aziridinyl)phosphinate]; 2'-Deoxythymidine 3'-acetate 5'-[bis(2,2-dimethyl-1-aziridinyl)phosphinate]; AZT Phosphoramidate Analog (Intermediate); Nucleoside Aziridinyl Phosphinate Ester; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of Thymidine 3'-Acetate=5'-[Bis(2,2-Dimethyl-1-Aziridinyl)Phosphinic Acid] is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the stringent requirements of research and pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (by NMR and MS), and impurity profile is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.