Description

n-Propionyl-(4S,5R)-4-Methyl-5-Phenyl-2-Oxazolidinone is a high-purity, chiral oxazolidinone derivative widely utilized as a versatile chiral auxiliary and building block in asymmetric synthesis. This compound is critical for enabling the stereoselective construction of complex molecules, ensuring high enantiomeric purity in final products. It is an essential reagent for research and development laboratories and production facilities in the pharmaceutical and fine chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Employed to control stereochemistry in aldol, alkylation, and Diels-Alder reactions.
• Pharmaceutical Intermediate: Key building block for the synthesis of enantiomerically pure drugs and bioactive molecules.
• Academic & Industrial R&D: Used in process chemistry development and methodological studies for new synthetic routes.
• Catalyst and Ligand Precursor: Serves as a starting material for the preparation of chiral catalysts and ligands.
• Fine Chemical Production: Integral in the manufacture of specialty chemicals requiring specific stereochemical configurations.

Basic Information

Product Name	n-Propionyl-(4S,5R)-4-Methyl-5-Phenyl-2-Oxazolidinone
CAS No.	77877-20-4
Molecular Formula	C14H17NO3
Molecular Weight	247.29 g/mol
Synonyms	(4S,5R)-4-Methyl-5-phenyl-3-(propionyl)-2-oxazolidinone; (4S,5R)-N-Propionyl-4-methyl-5-phenyl-2-oxazolidinone; Propionic acid (4S,5R)-4-methyl-5-phenyl-2-oxo-3-oxazolidinyl ester; Evans Chiral Auxiliary Derivative; (S,R)-N-Propionyl-4-methyl-5-phenyloxazolidin-2-one
EINECS	Contact for details

Quality Control

Our n-Propionyl-(4S,5R)-4-Methyl-5-Phenyl-2-Oxazolidinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity (enantiomeric excess) and chemical purity assays, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.