Description

Sodium [5R-[5Alpha,6Alpha(R*)]]-3-(Ethylthio)-6-(1-Hydroxyethyl)-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylate CAS NO 77646-84-5 is a high-purity, non-natural β-lactam compound that serves as a critical advanced pharmaceutical intermediate. Its primary value lies in its role as a key building block for the synthesis of novel cephalosporin antibiotics, enabling the development of next-generation therapeutics. This product is essential for research institutions and pharmaceutical manufacturers focused on antibiotic discovery, process development, and the production of specialized active pharmaceutical ingredients (APIs).

Application

• Synthesis of Advanced Cephalosporin Antibiotics: Acts as a core intermediate for constructing novel β-lactam structures with potentially enhanced efficacy.
• Pharmaceutical Research & Development (R&D): Used in medicinal chemistry for creating and testing new antibiotic candidates against resistant bacterial strains.
• Process Chemistry and Scale-Up: Employed in optimizing synthetic routes for the cost-effective and scalable production of target APIs.
• Active Pharmaceutical Ingredient (API) Manufacturing: Integrated into the final synthesis steps for producing finished drug substances in cGMP environments.
• Bioconjugation and Prodrug Development: Utilized to create targeted antibiotic therapies with improved pharmacokinetic profiles.

Basic Information

Product Name	Sodium [5R-[5Alpha,6Alpha(R*)]]-3-(Ethylthio)-6-(1-Hydroxyethyl)-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylate
CAS No.	77646-84-5
Molecular Formula	C11H13NNaO4S2
Molecular Weight	318.34 g/mol
Synonyms	(5R,6R)-3-[(Ethylthio)methyl]-6-[(R)-1-hydroxyethyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid sodium salt; Sodium (5R,6R)-3-[(ethylthio)methyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; 7-Oxo-3-[(ethylthio)methyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-, sodium salt, (5R,6R)-; Cephalosporin C derivative sodium salt; β-lactam intermediate sodium salt
EINECS	Contact for details

Quality Control

Our Sodium [5R-[5Alpha,6Alpha(R*)]]-3-(Ethylthio)-6-(1-Hydroxyethyl)-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylate is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the exacting standards required for pharmaceutical synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each batch to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency. For long-term storage, consider desiccated or nitrogen-purged environments.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.