Description

4-Chlorotamoxifen is a chlorinated derivative of the well-known selective estrogen receptor modulator (SERM), tamoxifen. This compound is a critical pharmaceutical intermediate and research chemical used in the development and study of novel therapeutic agents targeting hormone-responsive pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in oncology and endocrinology research.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel tamoxifen analogs and potential anti-cancer drugs.
• Biochemical Research: Used as a reference standard and probe in studies of estrogen receptor (ER) binding affinity and mechanism of action.
• Metabolite Studies: Investigated as a potential metabolite or derivative in tamoxifen pharmacokinetic and metabolic pathway research.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to develop new SERMs with improved efficacy or reduced side effects.
• Academic Research: Employed in university and institutional labs for fundamental research in breast cancer biology and hormone signaling.
• Reference Material: Supplied as a high-purity certified reference material (CRM) for analytical method development and validation in quality control laboratories.

Basic Information

Product Name	4-Chlorotamoxifen
CAS No.	77588-46-6
Molecular Formula	C26H28ClNO
Molecular Weight	405.96 g/mol
Synonyms	(Z)-4-Chlorotamoxifen; 1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1,2-diphenyl-1-butene, 4'-Chloro derivative; 4'-Chlorotamoxifen; 4-Chloro-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1,2-diphenyl-1-butene; ICI 47699; Z-4-Chlorotamoxifen
EINECS	Contact for details

Quality Control

Our 4-Chlorotamoxifen is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including HPLC, NMR, and MS to ensure high chemical purity and structural identity. We provide full traceability and detailed Certificates of Analysis (COA) for all shipments, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.