Description

Isotrityrosine is a non-proteinogenic tyrosine derivative, a key intermediate in the synthesis of complex peptides and radiopharmaceuticals. Its unique isotopic labeling and structural properties make it a critical building block for research and development in targeted drug discovery and diagnostic imaging. This high-purity compound is essential for pharmaceutical R&D laboratories, academic research institutions, and manufacturers of advanced radiochemicals and peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel peptide-based drugs and therapeutic agents.
• Radiopharmaceutical Synthesis: Used in the development of radiolabeled compounds for Positron Emission Tomography (PET) and other diagnostic imaging techniques.
• Biochemical Research: Serves as a specialized reagent and reference standard in metabolic pathway studies and enzyme research.
• Peptide Chemistry: An important building block for constructing custom peptides with modified tyrosine residues for structure-activity relationship (SAR) studies.
• Isotope Labeling Studies: Employed in metabolic tracing and pharmacokinetic research due to its isotopic labeling potential.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Isotrityrosine
CAS No.	77533-78-9
Molecular Formula	C18H20N2O6
Molecular Weight	360.36 g/mol
Synonyms	L-Isotrityrosine; 3,3',5,5'-Tetraiodothyronine Impurity; Isotrityrosine (T3 related compound); 3,3',5-Triiodo-L-thyronine Related Compound A; O-(4-Hydroxybenzyl)-D-tyrosine; D-Tyrosine, O-(4-hydroxybenzyl)-; (R)-2-Amino-3-(4-((4-hydroxyphenyl)methoxy)phenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our Isotrityrosine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and pharmaceutical intermediate grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.