Description

Sulphanilamide-D4 CAS NO 77435-46-2 is a stable isotope-labeled analog of the classic antibacterial agent, sulfanilamide, where four hydrogen atoms are replaced by deuterium. This deuteration provides a crucial internal standard for precise quantitative analysis in mass spectrometry-based methods. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and life sciences sectors requiring high-accuracy measurements. Its primary value lies in enabling reliable pharmacokinetic studies, metabolic profiling, and ensuring the accuracy of analytical assays.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the accurate quantification of sulfanilamide and related compounds in complex biological matrices like plasma, urine, and tissue homogenates.
• Pharmacokinetic and Metabolism Research: Used in drug development studies to track the absorption, distribution, metabolism, and excretion (ADME) of sulfonamide drugs with high precision.
• Veterinary Drug Residue Analysis: Facilitates the detection and quantification of sulfonamide antibiotic residues in food-producing animals to ensure food safety and regulatory compliance.
• Biomarker Discovery and Validation: Employed in proteomic and metabolomic research to identify and quantify biomarkers related to bacterial infection or drug response.
• Pharmaceutical Quality Control: Ensures assay accuracy and method validation in the quality control testing of sulfonamide-containing pharmaceutical formulations.
• Environmental Monitoring: Aids in the trace analysis of sulfonamide contaminants in water and soil samples for environmental impact studies.

Basic Information

Product Name	Sulphanilamide-D4
CAS No.	77435-46-2
Molecular Formula	C6D4H4N2O2S
Molecular Weight	176.22 g/mol
Synonyms	4-Aminobenzenesulfonamide-d4; Sulfanilamide-d4; p-Aminobenzenesulfonamide-d4; Deuterosulfanilamide; [2H4]-Sulfanilamide; SN-D4; Para-aminobenzenesulfonamide-d4; Deuterated Sulfanilamide
EINECS	Contact for details

Quality Control

Every batch of Sulphanilamide-D4 is manufactured and analyzed under strict quality management protocols to ensure the highest isotopic and chemical purity required for analytical applications. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with industry standards for stable isotope-labeled compounds. Certificates of Analysis (COA) detailing isotopic purity, chemical purity, and analytical methods are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to maintain optimal stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0% (Chemical Purity)
Isotopic Purity (MS)	≥98 atom % D
Deuterium Content	≥97.5% (D4)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.