Description

n-(tert-Butyldimethylsilyl)-n-Methyl-Trifluoroacetamide is a specialized organosilicon reagent primarily used as a powerful silylating agent and protecting group precursor in advanced organic synthesis. Its value lies in its ability to introduce the sterically hindered tert-butyldimethylsilyl (TBDMS) group, offering superior stability for protecting sensitive functional groups like alcohols and amines under demanding reaction conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity intermediates for complex multi-step syntheses, including the production of active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for introducing protecting groups in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide and Oligonucleotide Chemistry: Used to protect hydroxyl and amino groups during the solid-phase or solution-phase synthesis of peptides and nucleic acid analogs.
• Natural Product and Agrochemical Research: Facilitates the synthesis of complex natural product analogs and advanced agrochemical intermediates by providing robust protection for sensitive moieties.
• Derivatization Agent for Analytical Chemistry: Employed to silylate compounds for Gas Chromatography-Mass Spectrometry (GC-MS) analysis, improving volatility and detection of polar analytes.
• Material Science Precursor: Serves as a building block for synthesizing specialized silicon-containing polymers and advanced hybrid materials.
• Process Chemistry and Scale-up: Valued for its reliability and consistency in kilogram-scale manufacturing processes within fine chemical production.

Basic Information

Product Name	n-(tert-Butyldimethylsilyl)-n-Methyl-Trifluoroacetamide
CAS No.	77377-52-7
Molecular Formula	C9H18F3NOSi
Molecular Weight	241.33 g/mol
Synonyms	N-Methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide; MTBSTFA; N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide; N-Methyl-N-(t-butyldimethylsilyl)trifluoroacetamide; TBDMS-N-methyltrifluoroacetamide; N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide; Silylating Agent MTBSTFA; N-Methyl-N-[(1,1-dimethylethyl)dimethylsilyl]-2,2,2-trifluoroacetamide
EINECS	Contact for details

Quality Control

Our n-(tert-Butyldimethylsilyl)-n-Methyl-Trifluoroacetamide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with data from GC, HPLC, and NMR, to verify identity, purity, and the absence of critical impurities. Our quality management system is designed to meet the stringent requirements of research and development as well as cGMP-guided production environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.