Description

Npys-Gly-Oh CAS NO 77357-00-7 is a specialized chemical building block, specifically an N-protected glycine derivative featuring the 3-nitro-2-pyridinesulfonyl (Npys) protecting group. This compound is valued for its role in advanced peptide synthesis and bioconjugation chemistry, where it provides selective deprotection capabilities under mild conditions. It is primarily required by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic peptides and protein-based products.

Application

• Peptide Synthesis: Used as a protected glycine derivative in solid-phase and solution-phase peptide synthesis.
• Bioconjugation: Serves as a key reagent for the selective modification of proteins, antibodies, and other biomolecules.
• Protecting Group Chemistry: The Npys group is utilized for the temporary protection of amino groups, allowing for orthogonal deprotection strategies in complex multi-step syntheses.
• Pharmaceutical Intermediate: Acts as a critical intermediate in the research and development of peptide-based active pharmaceutical ingredients (APIs).
• Chemical Biology Research: Employed in the study of protein-protein interactions and enzyme mechanisms through site-specific labeling.
• Ligand Development: Used in the creation of novel ligands for diagnostic assays and targeted drug delivery systems.

Basic Information

Product Name	Npys-Gly-Oh
CAS No.	77357-00-7
Molecular Formula	C₇H₇N₃O₆S
Molecular Weight	261.21 g/mol
Synonyms	N-(3-Nitro-2-pyridinesulfonyl)glycine; Glycine, N-[(3-nitro-2-pyridinyl)sulfonyl]-; 2-[(3-Nitropyridin-2-yl)sulfonylamino]acetic acid; Npys-Glycine; Npys-Gly-OH; 3-Nitro-2-pyridinesulfonyl glycine; N-(3-Nitro-2-pyridylsulfonyl)glycine
EINECS	Contact for details

Quality Control

Our Npys-Gly-Oh is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and synthesis applications. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.