Description

5,5,5-Trifluoropent-1-En-4-Ol is a specialized fluorinated building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a terminal alkene and a trifluoromethyl-substituted alcohol, makes it a valuable precursor for introducing fluorine-containing motifs into target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries. Its application is critical for the development of novel compounds with enhanced metabolic stability, bioavailability, and specific biological activity.

Application

• Pharmaceutical Intermediate: Serves as a key synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting improved drug-like properties.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the trifluoromethyl group can enhance biological efficacy and environmental stability.
• Liquid Crystal & Advanced Material Precursor: Acts as a building block for fluorinated organic compounds used in electronic displays and specialty polymers, leveraging fluorine's impact on dielectric constant and chemical resistance.
• Cross-Coupling & Functionalization Reactions: The alkene and alcohol functionalities provide handles for further chemical transformations, such as olefin metathesis, oxidation, or nucleophilic substitution, to create complex fluorinated architectures.
• Fluorine-19 NMR Probe Development: Can be incorporated into molecules as a sensitive 19F NMR tag for biochemical and materials science research due to the distinctive NMR signal of the CF3 group.

Basic Information

Product Name	5,5,5-Trifluoropent-1-En-4-Ol
CAS No.	77342-37-1
Molecular Formula	C5H7F3O
Molecular Weight	140.10 g/mol
Synonyms	4-Penten-1-ol, 5,5,5-trifluoro-; 5,5,5-Trifluoro-4-penten-1-ol; 5,5,5-Trifluoropent-4-en-1-ol; 4-Penten-1-ol, 5,5,5-trifluoro- (9CI); 5,5,5-Trifluoro-1-penten-4-ol; Trifluoropentenol; 77342-37-1
EINECS	Contact for details

Quality Control

Our 5,5,5-Trifluoropent-1-En-4-Ol is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for traceability and documentation, ensuring reliable supply for critical synthetic pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is sensitive to strong bases and fluorides; keep away from incompatible materials. For long-term storage, consider maintaining under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 95.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.