Description

2-([4-(Trifluoromethyl)Phenyl]Amino)Acetic Acid CAS NO 77311-21-8 is a specialized organic compound featuring a trifluoromethylphenylaminoacetic acid backbone, serving as a key building block in advanced chemical synthesis. Its molecular structure, combining an amino acid moiety with a trifluoromethylphenyl group, makes it a valuable intermediate for creating compounds with enhanced biological activity and physicochemical properties. This high-purity intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting inflammation, CNS disorders, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve efficacy and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis, useful in asymmetric synthesis.
• Material Science Research: Employed in the development of advanced organic materials, including liquid crystals and polymers with specific electronic or optical properties.
• Bioconjugation and Probe Synthesis: Useful for modifying biomolecules or creating fluorescent probes and tags for biochemical and diagnostic applications.

Basic Information

Product Name	2-([4-(Trifluoromethyl)Phenyl]Amino)Acetic Acid
CAS No.	77311-21-8
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	N-[4-(Trifluoromethyl)phenyl]glycine; (4-Trifluoromethylphenylamino)acetic Acid; 2-[[4-(Trifluoromethyl)phenyl]amino]acetic Acid; 2-Amino-N-[4-(trifluoromethyl)phenyl]acetamide (tautomeric form); Glycine, N-[4-(trifluoromethyl)phenyl]-; 4-Trifluoromethylanilinoacetic Acid; α-((4-Trifluoromethyl)anilino)acetic Acid
EINECS	Contact for details

Quality Control

Our production of 2-([4-(Trifluoromethyl)Phenyl]Amino)Acetic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry to confirm identity and quantify impurities. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, and our quality system supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.