Description

Boc-L-2-Aminoadipic Acid CAS NO 77302-72-8 is a protected amino acid derivative, specifically the tert-butoxycarbonyl (Boc) derivative of L-2-aminoadipic acid, serving as a crucial chiral building block in organic synthesis. Its primary value lies in providing a protected amine group, which is essential for the controlled, sequential construction of complex peptides and other bioactive molecules. This high-purity intermediate is indispensable for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries, particularly in the development of novel peptide-based therapeutics and advanced materials.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the aminoadipic acid residue with orthogonal protection.
• Bioconjugation & Linker Chemistry: Serves as a component in the design of chemical linkers and spacers for antibody-drug conjugates (ADCs) and other bioconjugates.
• Research & Development: Essential reagent in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new bioactive compounds.
• Fine Chemical Synthesis: Intermediate in the multi-step synthesis of complex natural products, specialty chemicals, and advanced materials.
• Biochemical Tool: Used in the study of metabolic pathways involving aminoadipic acid, such as the lysine degradation pathway.

Basic Information

Product Name	Boc-L-2-Aminoadipic Acid
CAS No.	77302-72-8
Molecular Formula	C11H19NO6
Molecular Weight	261.27 g/mol
Synonyms	(2S)-2-{[(tert-Butoxy)carbonyl]amino}hexanedioic acid; N-(tert-Butoxycarbonyl)-L-2-aminoadipic acid; Boc-L-α-Aminoadipic acid; N-Boc-L-2-aminoadipic acid; Boc-Aad-OH; Nα-Boc-L-2-aminoadipic acid; L-2-((tert-Butoxycarbonyl)amino)adipic acid; BOC-2-AMINOADIPIC ACID (L)
EINECS	Contact for details

Quality Control

Our Boc-L-2-Aminoadipic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide Certificates of Analysis (COA) with detailed specifications for traceability and quality assurance, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.