Description

Ac-Ser(Tbu)-Oh CAS NO 77285-09-7 is a protected serine derivative, specifically N-Acetyl-O-tert-butyl-L-serine, widely used as a key building block in peptide synthesis. This compound is critical for researchers and manufacturers who require precise control over amino acid side-chain reactivity during the construction of complex peptide chains. It is an essential intermediate for the pharmaceutical, biotechnology, and life science research industries, enabling the development of novel therapeutic peptides and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the controlled incorporation of serine residues with orthogonal side-chain protection.
• Solution-Phase Peptide Synthesis: Used in the synthesis of peptide fragments and small peptides where tert-butyl protection is advantageous.
• Pharmaceutical Intermediates: Serves as a critical raw material in the research and production of active pharmaceutical ingredients (APIs) for peptide-based drugs.
• Bioconjugation and Labeling: The acetylated amine and protected hydroxyl group provide specific handles for further chemical modification and labeling studies.
• Biochemical Research: Employed in academic and industrial R&D for studying protein structure-function relationships and enzyme substrates.
• Combinatorial Chemistry: Used in libraries for drug discovery to explore structure-activity relationships (SAR) of peptide analogs.

Basic Information

Product Name	Ac-Ser(Tbu)-Oh
CAS No.	77285-09-7
Molecular Formula	C9H17NO4
Molecular Weight	203.24 g/mol
Synonyms	N-Acetyl-O-tert-butyl-L-serine; Acetyl-O-tert-butylserine; N-Acetyl-3-[(2-methylpropan-2-yl)oxy]-L-alanine; L-Serine, N-acetyl-, O-(1,1-dimethylethyl) ester; Ac-Ser(OtBu)-OH; Fmoc-Ser(tBu)-OH precursor; Serine derivative, protected; Boc-Ser(tBu)-OH related compound
EINECS	Contact for details

Quality Control

Every batch of Ac-Ser(Tbu)-Oh is produced and tested under a strict quality management system to ensure consistency and reliability for your critical applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality standards are designed to meet the rigorous demands of pharmaceutical intermediate and research-grade chemical supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.