Description

tert-Butyl 4-(2-Hydroxyethyl)piperazine-1-carboxylate is a versatile and high-purity piperazine derivative, serving as a critical building block in advanced organic synthesis. Its bifunctional structure, featuring both a protected amine and a terminal hydroxyl group, makes it an essential intermediate for constructing complex molecules with precise pharmacological activity. This compound is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• API Synthesis: Used as a core scaffold for constructing active pharmaceutical ingredients (APIs) that incorporate a functionalized piperazine moiety.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for metal catalysis and organocatalysts used in asymmetric synthesis.
• Polymer Chemistry: Acts as a monomer or chain extender in the production of specialty polymers, such as polyurethanes and polyamides, with tailored properties.
• Agrochemical Research: Serves as an intermediate in the development of new generation herbicides, fungicides, and plant growth regulators.
• Bioconjugation and Linker Chemistry: The hydroxyl group facilitates its use in creating cleavable linkers for antibody-drug conjugates (ADCs) and other bioconjugation applications.

Basic Information

Product Name	tert-Butyl 4-(2-Hydroxyethyl)piperazine-1-carboxylate
CAS No.	77279-24-4
Molecular Formula	C11H22N2O3
Molecular Weight	230.31 g/mol
Synonyms	1-Boc-4-(2-hydroxyethyl)piperazine; N-Boc-4-(2-hydroxyethyl)piperazine; 4-(2-Hydroxyethyl)piperazine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(2-hydroxyethyl)-1-piperazinecarboxylate; 1-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperazine; N-tert-Butoxycarbonyl-4-(2-hydroxyethyl)piperazine; 2-(1-Boc-piperazin-4-yl)ethanol; Boc-Pip-CH2CH2OH
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Hydroxyethyl)piperazine-1-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistent performance for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where required, ensuring reliability for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.