Description

Boc-Dap-Otbu CAS NO 77215-54-4 is a protected amino acid derivative, specifically N-tert-Butoxycarbonyl-D-2,3-diaminopropionic acid tert-butyl ester, widely used as a critical building block in peptide synthesis. Its value lies in providing orthogonal protection for both the α-amino and side-chain amino groups, enabling precise and sequential peptide chain elongation. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of diaminopropionic acid residues into complex peptide sequences.
• Pharmaceutical Research: Used in the development of peptide drugs, enzyme inhibitors, and receptor ligands where the Dap side chain is crucial for bioactivity.
• Linker and Conjugate Chemistry: The differentially protected amino groups allow for selective conjugation with other molecules, such as fluorescent dyes, drugs, or polymers.
• Combinatorial Chemistry Libraries: Serves as a versatile scaffold for generating diverse libraries of compounds for high-throughput screening.
• Glycopeptide Synthesis: Facilitates the synthesis of peptides containing sugar-amino acid linkages.
• Production of Custom Peptides: Essential for CROs and CDMOs offering bespoke peptide synthesis services for academic and industrial clients.

Basic Information

Product Name	Boc-Dap-Otbu
CAS No.	77215-54-4
Molecular Formula	C₁₃H₂₆N₂O₄
Molecular Weight	274.36 g/mol
Synonyms	N-Boc-D-2,3-Diaminopropionic Acid tert-Butyl Ester; (R)-2-((tert-Butoxycarbonyl)amino)-3-((tert-butoxycarbonyl)amino)propanoic Acid; tert-Butyl N-[(2R)-2-[(tert-butoxycarbonyl)amino]-3-carboxypropyl]carbamate; Boc-D-Dap(OtBu)-OH; Boc-D-Dap(Boc)-OtBu; Nα,Nβ-Bis-Boc-D-2,3-diaminopropionic acid tert-butyl ester; D-2,3-Diaminopropionic acid, Nα,Nβ-bis(tert-butoxycarbonyl)-, tert-butyl ester
EINECS	Contact for details

Quality Control

Our Boc-Dap-Otbu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive applications like pharmaceutical research. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to relevant industry standards and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.