Description

5-Fluoro-1-(β-L-Ribofuranosyl)Uracil is a fluorinated nucleoside analog, a key intermediate in the synthesis of antiviral and anticancer pharmaceuticals. This compound is valued for its role in the development of novel therapeutic agents, particularly those targeting viral replication and cellular proliferation. It is primarily required by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in nucleoside chemistry and prodrug development.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of antiviral and antineoplastic (anticancer) nucleoside analogs.
• Biochemical Research: Used in studies of enzyme inhibition, nucleic acid metabolism, and mechanism of action for fluoropyrimidine-based drugs.
• Prodrug Development: Serves as a precursor in creating more bioavailable or targeted prodrug forms of active pharmaceutical ingredients (APIs).
• Antiviral Agent Synthesis: Key starting material for compounds investigated for activity against various DNA and RNA viruses.
• Labeled Compound Synthesis: Can be used to prepare isotopically labeled versions (e.g., with C-13, N-15) for metabolic and pharmacokinetic studies.
• Reference Standard: Employed as a high-purity analytical standard for quality control in API manufacturing.

Basic Information

Product Name	5-Fluoro-1-(β-L-Ribofuranosyl)Uracil
CAS No.	77210-26-5
Molecular Formula	C9H11FN2O6
Molecular Weight	262.19 g/mol
Synonyms	5-Fluorouridine; 5-Fluoro-1-β-L-ribofuranosyluracil; 5-Fluoro-β-L-uridine; 1-β-L-Ribofuranosyl-5-fluorouracil; 5-FUrd (β-L-isomer); L-5-Fluorouridine; 5-Fluoro-1-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)pyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our 5-Fluoro-1-(β-L-Ribofuranosyl)Uracil is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediate use. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.