Description

5 - Chloro-Acetamido-N, N - Bis (2,3 - Dihydroxypropyl) -2,4,6 - Triiodo-1 ,3. Phthalimido is a high-purity, tri-iodinated organic compound primarily used as a key intermediate in the synthesis of advanced X-ray contrast media. Its molecular structure, featuring three iodine atoms, is critical for imparting the radiopacity required in diagnostic imaging agents. This compound is essential for manufacturers in the pharmaceutical and fine chemical sectors developing non-ionic, low-osmolar contrast agents for enhanced patient safety and diagnostic clarity.

Application

• Primary Intermediate for X-ray Contrast Media: Serves as the core building block in the synthesis of modern, non-ionic iodinated contrast agents used in CT scans, angiography, and urography.
• Pharmaceutical Research & Development: Utilized in the R&D of next-generation diagnostic imaging compounds with improved safety profiles and pharmacokinetics.
• Fine Chemical Synthesis: Employed in complex organic synthesis routes requiring precise, multi-functional iodinated intermediates.
• Contrast Agent Formulation: Used in the production of final drug formulations, ensuring high radiopacity and biocompatibility.

Basic Information

Product Name	5 - Chloro-Acetamido-N, N - Bis (2,3 - Dihydroxypropyl) -2,4,6 - Triiodo-1 ,3. Phthalimido
CAS No.	77203-11-3
Molecular Formula	C₁₆H₁₇ClI₃N₃O₆
Molecular Weight	787.49 g/mol
Synonyms	5-Chloroacetamido-N,N-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide; Iomeprol Intermediate; Iopamidol Related Compound; 5-(Chloroacetamido)-N,N-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide; 77203-11-3; Triiodinated Phthalimido Derivative; Non-ionic Contrast Agent Intermediate
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality management systems, with specifications designed to meet the exacting standards of pharmaceutical manufacturing. Each batch is tested using advanced analytical techniques including HPLC, NMR, and IR spectroscopy to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all critical parameters. Production can be aligned with cGMP guidelines upon request for regulated applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.