Description

Caffeine, [1-Methyl-14C] is a high-purity, carbon-14 labeled isotopologue of caffeine, a naturally occurring alkaloid. This radiolabeled compound is essential for conducting precise metabolic, pharmacokinetic, and environmental fate studies, providing critical data on absorption, distribution, metabolism, and excretion (ADME). It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced biochemical research and regulatory safety testing.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Tracing the metabolic pathways and bioavailability of caffeine and related xanthine derivatives in preclinical and clinical research.
• Environmental Toxicology: Investigating the biodegradation, bioaccumulation, and environmental fate of caffeine and its metabolites in ecological systems.
• Biochemical Pathway Analysis: Serving as a tracer in studies of purine metabolism, enzymatic activity (e.g., cytochrome P450), and receptor binding assays.
• Analytical Method Development: Acting as an internal standard or reference material in Liquid Chromatography-Mass Spectrometry (LC-MS) and other chromatographic techniques for quantitative analysis.
• Nutritional Science Research: Studying the detailed absorption, distribution, and clearance mechanisms of caffeine in human and animal models.

Basic Information

Product Name	Caffeine, [1-Methyl-14C]
CAS No.	77196-81-7
Molecular Formula	C8H1014CN4O2
Molecular Weight	~196.2 g/mol (for unlabeled form)
Synonyms	1,3,7-Trimethyl-*1-methyl-*14C-xanthine; [1-Methyl-14C]Caffeine; Caffeine-1-14C; Caffeine (methyl-14C); 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione (1-14C-methyl); Theine-14C; Guaranine-14C; Methyltheobromine-14C
EINECS	Contact for details

Quality Control

Every batch of Caffeine, [1-Methyl-14C] is manufactured and analyzed under strict quality systems to ensure high chemical and radiochemical purity, specific activity, and stability. Our quality commitment includes comprehensive analytical characterization using techniques such as HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA), specifying purity, radiochemical concentration, and solvent details, is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures (typically 2-8°C or as specified on the label) in a dedicated, well-ventilated area for radioactive materials. This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 98% (Chemical Purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for specific value)
Solvent (if supplied as solution)	Ethanol, Methanol, or as specified
Concentration (if supplied as solution)	1.0 mCi/mL ± 10% (or as specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.