Description

Fenclofenac Glucuronide is a major, pharmacologically inactive metabolite of the non-steroidal anti-inflammatory drug (NSAID) fenclofenac. This compound is of significant value in pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It serves as a critical reference standard for laboratories in the pharmaceutical, contract research organization (CRO), and academic sectors requiring high-purity analytical markers.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for quantitative and qualitative analysis in drug development.
• Metabolite Identification & Profiling: Essential for in vitro and in vivo studies to map the metabolic pathways of Fenclofenac.
• Bioanalytical Method Development: Used to validate HPLC, LC-MS, and LC-MS/MS methods for the accurate detection and quantification of fenclofenac and its metabolites in biological matrices.
• Pharmacokinetic (PK) Studies: Employed as a calibration standard to determine drug clearance rates and metabolic stability.
• Impurity Profiling: Serves as a known impurity or degradation product standard for fenclofenac drug substance and product quality control.
• Toxicology & Safety Assessment: Used in studies to understand the safety profile and excretion mechanisms of fenclofenac.

Basic Information

Product Name	Fenclofenac Glucuronide
CAS No.	77182-37-7
Molecular Formula	C22H22Cl2O9
Molecular Weight	501.31 g/mol
Synonyms	Fenclofenac β-D-Glucuronide; 1-O-{4-[(2,4-Dichlorophenyl)amino]phenyl}acetyl-β-D-glucopyranuronic acid; Fenclofenac 1-O-β-Acid Glucuronide; Fenclofenac Acyl Glucuronide; Fenclofenac Glucuronic Acid Conjugate; Fenclofenac Metabolite; BRL 13856 Glucuronide
EINECS	Contact for details

Quality Control

Our Fenclofenac Glucuronide is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from HPLC, NMR, and MS analyses. We adhere to stringent in-house quality standards suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.