Description

Fmoc-n-Methyl-L-Phenylalanine CAS NO 77128-73-5 is a high-purity, protected amino acid derivative essential for modern peptide synthesis. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled introduction of a modified phenylalanine residue with an N-methylated backbone. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and CROs engaged in the development of novel therapeutic peptides, peptidomimetics, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block (Fmoc-amino acid) for the automated, stepwise construction of complex peptide chains.
• Pharmaceutical Research & Development: Synthesis of peptide-based drug candidates, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Peptidomimetic Design: Incorporation of N-methylated amino acids to enhance metabolic stability, membrane permeability, and bioavailability of peptide leads.
• Combinatorial Chemistry Libraries: Used to create diverse arrays of peptides for high-throughput screening against biological targets.
• Bioconjugation & Probe Development: Serves as a modified precursor for creating labeled peptides used in diagnostics and imaging.
• Academic Research: Studying protein-protein interactions, structure-activity relationships (SAR), and peptide folding.

Basic Information

Item	Details
Product Name	Fmoc-n-Methyl-L-Phenylalanine
CAS No.	77128-73-5
Molecular Formula	C25H23NO4
Molecular Weight	401.46 g/mol
Synonyms	Fmoc-N-Me-Phe-OH; Fmoc-N-Methyl-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl(methyl)amino]-3-phenylpropanoic acid; N-Fmoc-N-methyl-L-phenylalanine; Fmoc-N-methylphenylalanine; N-α-Fmoc-N-methyl-L-phenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-n-Methyl-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via NMR and mass spectrometry. We provide a Certificate of Analysis (COA) with every shipment, detailing all critical specifications to ensure compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.