Description

Fmoc-Sarcosine Monohydrate is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for introducing the unique N-methylglycine (sarcosine) moiety into peptide chains, which can enhance metabolic stability and alter conformational properties. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing novel therapeutic peptides, peptidomimetics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid for the automated, stepwise construction of complex peptide sequences.
• Pharmaceutical Research: Key intermediate in the development of peptide-based drugs where sarcosine incorporation is desired for improved bioavailability or activity.
• Peptidomimetic Design: Used to create modified peptide analogs with enhanced stability against enzymatic degradation.
• Bioconjugation: Acts as a linker or spacer molecule in the synthesis of peptide-protein or peptide-small molecule conjugates.
• Chemical Biology Probes: Synthesis of labeled or tagged peptides for studying protein-protein interactions and cellular processes.
• Academic Research: Fundamental studies in organic chemistry and peptide science for method development and exploration of structure-activity relationships.

Basic Information

Product Name	Fmoc-Sarcosine Monohydrate
CAS No.	77128-70-2
Molecular Formula	C19H19NO5 • H2O
Molecular Weight	359.37 g/mol (Monohydrate)
Synonyms	Fmoc-Sar-OH • H2O; N-(9-Fluorenylmethoxycarbonyl)-N-methylglycine Monohydrate; N-Fmoc-sarcosine Monohydrate; (9H-Fluoren-9-ylmethoxy)carbonyl-methyl-amino-acetic acid monohydrate; Fmoc-N-methyl-glycine monohydrate; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylglycine monohydrate; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]sarcosine monohydrate
EINECS	Contact for details

Quality Control

Our Fmoc-Sarcosine Monohydrate is manufactured under strict quality control protocols to ensure consistency and high purity suitable for sensitive peptide synthesis applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to current industry best practices, and our quality system supports the requirements of customers operating under cGMP guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	4.5% - 6.5%
Optical Rotation	Contact for details
Heavy Metals	<20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.