Description

o-[3,5-Diiodo-4-(Sulfooxy)Phenyl]-3,5-Diiodo L-Tyrosine is a highly functionalized, iodinated derivative of the amino acid L-tyrosine, featuring a sulfated phenolic group. This unique molecular architecture makes it a critical intermediate for the synthesis of specialized diagnostic agents and pharmaceutical compounds, particularly in the field of thyroid hormone research and radiopharmaceuticals. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in developing novel contrast media, targeted therapies, and biochemical probes. The compound's specific reactivity and structure are essential for creating molecules with high biological specificity and binding affinity.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of thyroid hormone analogs and receptor-targeted drugs.
• Diagnostic Agent Precursor: Used in the research and development of radioiodinated compounds for medical imaging (e.g., SPECT agents).
• Biochemical Research: Serves as a specialized substrate or inhibitor in enzymatic studies related to tyrosine metabolism and sulfation pathways.
• Contrast Media Development: Intermediate for creating X-ray or MRI contrast agents due to the high atomic number of iodine.
• Proteomics & Labeling: Potential use in the design of affinity labels or photoaffinity probes for protein binding studies.
• Reference Standard: Serves as a high-purity analytical standard for quality control in pharmaceutical manufacturing and regulatory testing.

Basic Information

Product Name	o-[3,5-Diiodo-4-(Sulfooxy)Phenyl]-3,5-Diiodo L-Tyrosine
CAS No.	77074-49-8
Molecular Formula	C15H10I4NO6S
Molecular Weight	835.86 g/mol
Synonyms	3,3',5,5'-Tetraiodothyronine Sulfate; T4 Sulfate; L-Thyroxine Sulfate; O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine Sulfate; 3,5,3',5'-Tetraiodothyronine Sulfate Ester; Thyroxine Sulfate; 4-(Sulfooxy)-3,5-diiodophenyl 3,5-Diiodo-4-hydroxyphenylalanine; L-T4 Sulfate
EINECS	Contact for details

Quality Control

Our o-[3,5-Diiodo-4-(Sulfooxy)Phenyl]-3,5-Diiodo L-Tyrosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and specific tests for residual solvents and heavy metals, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a desiccated environment. For long-term storage, consider inert atmosphere conditions to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.