Description

n-(1-Pyrene)Iodoacetamide is a high-purity, functionalized pyrene derivative designed for advanced research and development. This compound serves as a critical building block and labeling reagent, enabling the study and modification of biomolecules through its reactive iodoacetamide group and fluorescent pyrene moiety. It is essential for scientists in bioconjugation, proteomics, and materials science who require precise, fluorescent tagging and cross-linking capabilities.

Application

• Bioconjugation and Protein Labeling: Used to selectively modify cysteine residues in proteins and peptides for fluorescence studies, activity-based protein profiling (ABPP), and the creation of antibody-drug conjugates (ADCs).
• Fluorescent Probe Synthesis: Acts as a key precursor for developing sensitive fluorescent sensors and probes for detecting metal ions, small molecules, or enzymatic activity.
• Polymer and Materials Science: Employed to functionalize polymers, nanoparticles, and surfaces with pyrene fluorophores for creating smart materials, sensors, or studying polymer dynamics via fluorescence.
• Nucleic Acid Research: Utilized for labeling oligonucleotides to investigate nucleic acid structure, dynamics, and protein-nucleic acid interactions.
• Cross-linking Agent: Serves as a photo-cross-linker or chemical cross-linker in structural biology to capture and analyze transient molecular interactions.

Basic Information

Product Name	n-(1-Pyrene)Iodoacetamide
CAS No.	76936-87-3
Molecular Formula	C20H14INO
Molecular Weight	411.24 g/mol
Synonyms	1-Pyreneacetamide, N-(iodoacetyl)-; N-(Iodoacetyl)-1-pyrenamine; 1-Pyreneiodoacetamide; Pyrene iodoacetamide; N-(1-Pyrenyl)iodoacetamide; Iodoacetamidopyrene; 1-Pyrenyl iodoacetamide; N-(1-Pyrene)iodoacetamide
EINECS	Contact for details

Quality Control

Our n-(1-Pyrene)Iodoacetamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research applications. Each lot is characterized by multiple analytical techniques, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility Test	Soluble in DMF, DMSO, Acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.