Description

n-(3-Nitro-2-Pyridinesulfenyl)-L-Leucine is a specialized amino acid derivative used as a key reagent in peptide synthesis. This compound matters for its role as a protecting group, enabling the selective modification and controlled assembly of complex peptide chains. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, APIs, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Acts as a temporary protecting group for the amino function of L-leucine, facilitating the sequential addition of amino acids.
• Solution-Phase Peptide Chemistry: Used in the synthesis of complex or sensitive peptides where traditional protecting groups are unsuitable.
• Pharmaceutical Intermediate: Serves as a critical building block in the research and production of peptide-based Active Pharmaceutical Ingredients (APIs).
• Bioconjugation: Employed in the site-specific modification of proteins and other biomolecules for drug delivery or diagnostic applications.
• Chemical Biology Research: Utilized in the study of protein-protein interactions and the development of enzyme inhibitors or probes.
• Custom Peptide Service Providers: A key reagent for CROs and CDMOs offering bespoke peptide synthesis services to the biotech industry.

Basic Information

Product Name	n-(3-Nitro-2-Pyridinesulfenyl)-L-Leucine
CAS No.	76863-77-9
Molecular Formula	C11H15N3O4S
Molecular Weight	285.32 g/mol
Synonyms	N-(3-Nitro-2-pyridinylthio)-L-leucine; N-(3-Nitro-2-pyridinesulfenyl)-L-leucine; L-Leucine, N-[(3-nitro-2-pyridinyl)thio]-; Npys-Leu-OH; 3-Nitro-2-pyridinesulfenyl-L-leucine; N-(3-Nitro-2-pyridylthio)-L-leucine; Npys-L-Leucine
EINECS	Contact for details

Quality Control

Our n-(3-Nitro-2-Pyridinesulfenyl)-L-Leucine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.