Description

Desethylprocainamide is a key pharmaceutical intermediate and metabolite of the antiarrhythmic drug procainamide. This compound is of significant importance for research and development in the fields of pharmacology, pharmacokinetics, and analytical chemistry. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions for drug metabolism studies, impurity profiling, and as a reference standard in quality control laboratories.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of procainamide metabolites in drug substance and finished product analysis.
• Metabolite Research: Essential for in vitro and in vivo studies investigating the metabolic pathways, pharmacokinetics, and pharmacodynamics of procainamide.
• Impurity Profiling: Serves as a critical impurity marker in the quality control of procainamide API (Active Pharmaceutical Ingredient) to ensure product safety and compliance with ICH guidelines.
• Clinical Toxicology: Employed in the development and validation of diagnostic assays for therapeutic drug monitoring (TDM) and overdose cases.
• Biochemical Research: Used as a tool compound in studies exploring cardiac ion channel interactions and the mechanisms of antiarrhythmic drugs.
• Method Development: A vital component for developing and validating analytical methods, such as HPLC, LC-MS/MS, and GC-MS, for pharmaceutical analysis.

Basic Information

Product Name	Desethylprocainamide
CAS No.	76806-95-6
Molecular Formula	C11H17N3O
Molecular Weight	207.27 g/mol
Synonyms	N-(4-Aminobenzoyl)-N',N'-diethylethylenediamine; N4-(Diethylaminoethyl)sulfanilamide impurity; Procainamide metabolite; N-Acetylprocainamide impurity A; NAPA metabolite; 4-Amino-N-[2-(diethylamino)ethyl]benzamide; DEPA
EINECS	Contact for details

Quality Control

Our Desethylprocainamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all test results against predefined specifications is provided with every shipment to ensure traceability and compliance with research and pharmaceutical standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0% w/w
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.