Description

(R)-4-Hydroxy Propranolol CAS NO 76792-97-7 is a high-purity, chiral metabolite of the widely used β-blocker, propranolol. This compound is of significant value in pharmaceutical research and development, serving as a critical reference standard and a key intermediate for synthesizing novel active pharmaceutical ingredients (APIs). It is primarily needed by research institutions, analytical laboratories, and pharmaceutical companies engaged in cardiovascular drug development, metabolic studies, and chiral synthesis.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of propranolol and its metabolites in drug development and bioanalytical studies.
• Metabolite Research: Essential for studying the pharmacokinetics, pharmacodynamics, and metabolic pathways of propranolol in preclinical and clinical research.
• Chiral Intermediate: Serves as a key building block in the asymmetric synthesis of more complex, stereospecific β-adrenergic blocking agents.
• Analytical Method Development: Employed to develop and validate chromatographic methods (HPLC, LC-MS) for the separation and detection of drug enantiomers and metabolites.
• Impurity Profiling: Acts as a known impurity standard to monitor and control the quality of propranolol API batches during manufacturing.
• Biochemical Research: Utilized in receptor-binding assays and studies investigating the stereospecific effects of β-blockers on cellular signaling pathways.

Basic Information

Product Name	(R)-4-Hydroxy Propranolol
CAS No.	76792-97-7
Molecular Formula	C₁₆H₂₁NO₃
Molecular Weight	275.34 g/mol
Synonyms	(R)-4-Hydroxypropranolol; 1-[(1R)-2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-4-hydroxynaphthalene; 4-Hydroxypropranolol, (R)-; (R)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol, 4-Hydroxy-; 4-Hydroxypropranolol enantiomer; Propranolol metabolite 4-OH (R-form); (R)-1-(Isopropylamino)-3-[(4-hydroxy-1-naphthyl)oxy]-2-propanol
EINECS	Contact for details

Quality Control

Our (R)-4-Hydroxy Propranolol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.