Description

Cloxacillin Sulfone is a key chemical intermediate and reference standard derived from the β-lactam antibiotic cloxacillin. This compound is of significant importance in pharmaceutical research and development, particularly in the study of antibiotic degradation pathways and the synthesis of novel derivatives. It is primarily utilized by manufacturers and research institutions in the pharmaceutical, biotechnology, and analytical chemistry sectors for method development, quality control, and advanced synthetic applications.

Application

• Pharmaceutical Intermediate: A critical building block in the research and synthesis of novel β-lactam compounds and antibiotic analogs.
• Analytical Reference Standard: Used for method development, validation, and quality control testing in HPLC, LC-MS, and other chromatographic systems to identify and quantify related substances.
• Degradation Product Studies: Essential for stability testing and impurity profiling of cloxacillin sodium and related penicillin-based drugs.
• Biochemical Research: Employed in studies investigating bacterial resistance mechanisms and the activity of β-lactamase enzymes.
• Chemical Synthesis: Serves as a precursor for the preparation of more complex sulfone-containing molecules for pharmacological evaluation.

Basic Information

Product Name	Cloxacillin Sulfone
CAS No.	76788-83-5
Molecular Formula	C19H17ClN2O6S
Molecular Weight	436.87 g/mol
Synonyms	(2S,5R,6R)-6-[[(2R)-2-Amino-2-(3-chlorophenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 1,1-dioxide; 5-Methyl-3-phenyl-4-isoxazolylpenicillin sulfone; Cloxacillin 1,1-Dioxide; Cloxacillin Sulfone Impurity; SQ 82,321
EINECS	Contact for details

Quality Control

Our Cloxacillin Sulfone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical intermediates and reference standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.