Description

(R)-Apomorphine-D4 Hydrochloride is a high-purity, deuterium-labeled isotopologue of the dopamine receptor agonist apomorphine. This compound is a critical analytical standard and reference material, essential for ensuring accuracy and reliability in quantitative bioanalytical studies. It is primarily utilized by pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism and pharmacokinetics (DMPK) research, method development, and quality control.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, non-interfering internal standard for the precise quantification of apomorphine in complex biological matrices such as plasma, serum, and tissue homogenates.
• Drug Metabolism Studies (DMPK): Used in mass spectrometry-based assays to track the absorption, distribution, metabolism, and excretion (ADME) profile of the parent drug, improving data accuracy.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling: Enables accurate measurement of drug concentration over time, which is fundamental for establishing dose-response relationships.
• Bioanalytical Method Development and Validation: A key component in developing, optimizing, and validating robust, regulatory-compliant analytical methods (e.g., for FDA/EMA submissions).
• Quality Control & Reference Standard: Acts as a certified reference material to calibrate equipment and verify the purity and concentration of apomorphine in pharmaceutical formulations.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-precision quantification techniques to achieve superior accuracy and minimize matrix effects.

Basic Information

Product Name	(R)-Apomorphine-D4 Hydrochloride
CAS No.	76787-63-8
Molecular Formula	C17H13D4NO2 • HCl
Molecular Weight	303.80 g/mol (for free base C17H13D4NO2)
Synonyms	Apomorphine-D4 HCl; (R)-6aβ-Aporphine-10,11-diol-D4 Hydrochloride; (R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol-D4 Hydrochloride; Deuterated Apomorphine Hydrochloride; d4-Apomorphine HCl; Apomorphine (D4) HCl; 10,11-Dihydroxyaporphine-D4 Hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-Apomorphine-D4 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical and isotopic purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium enrichment)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.