Description

Rac Ketoprofen Acyl-B-D-Glucuronide is a key glucuronide metabolite of the non-steroidal anti-inflammatory drug (NSAID) ketoprofen. This compound is of significant value for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily needed by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in bioanalytical method development, metabolite identification, and regulatory safety testing.

Application

• Metabolite Reference Standard: Serves as a critical certified reference material (CRM) for the accurate quantification of ketoprofen acyl glucuronide in biological matrices during preclinical and clinical studies.
• Pharmacokinetic & ADME Studies: Used in Absorption, Distribution, Metabolism, and Excretion (ADME) research to understand the metabolic pathway and clearance mechanisms of ketoprofen.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC, LC-MS, or LC-MS/MS methods for metabolite profiling and detection.
• Toxicology & Safety Assessment: Aids in investigating the potential reactivity and toxicity associated with acyl glucuronide metabolites, which is a key aspect of drug safety evaluation.
• Stability Studies: Employed in studies to assess the chemical stability and potential isomerization or hydrolysis of the acyl glucuronide under physiological conditions.
• Enzymology Research: Used as a substrate in studies investigating the activity and specificity of UDP-glucuronosyltransferase (UGT) enzymes.

Basic Information

Product Name	Rac Ketoprofen Acyl-B-D-Glucuronide
CAS No.	76690-94-3
Molecular Formula	C25H26O10
Molecular Weight	486.47 g/mol
Synonyms	Ketoprofen Acyl Glucuronide; Ketoprofen 1-O-β-Acyl Glucuronide; (RS)-Ketoprofen Acyl-β-D-Glucuronide; 2-(3-Benzoylphenyl)propionic acid 1-(β-D-glucopyranuronosyl) ester; Ketoprofen Glucuronide Metabolite; Rac-Ketoprofen Acyl Glucuronide; DL-Ketoprofen Acyl-β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our Rac Ketoprofen Acyl-B-D-Glucuronide is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency suitable for research applications. Each batch is characterized using advanced spectroscopic and chromatographic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term storage, keep at 2-8°C. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.